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This online resume is being updated and may not reflect my most recent edits.

# HEADLINE I work at the interface between mini-organ engineering and data science/automation. By leveraging the potential of alternative methods to animal models in predicting drug safety and performance, my goal is to help bridge the gap between in vitro biology and real world clinical outcomes. #MicrophysiologicalSystem #3R #HumanModels #HighThroughputBiology # INDUSTRIAL EXPERIENCES 2018 2022 Roche — Scientist / Senior Scientist Vascular Lab, investigative Safety Contributed to Roche expertise from 2D High-Throughput models to 3D Low-Throughput complex systems, with full automation in mind: Team efforts on vascular 2D cytotoxicity assays for derisking T-Cell bispecific antibodies (first in vitro-only package submitted to regulators before Entry into Human) Led a project to support drug evaluation in terms of adverse angiogenesis: - Implemented and up-scaled high-throughput 2.5D vasculogenesis and 3D angiogenesis models - Developed an HPC-based pipeline for ML-based image processing and dataviz/data analysis of vascular models. - Grant for the supervision of a PhD student to work on ML-based predictions of angiogenesis Implemented tissue sourcing and isolation strategies for autologous immunocompetent vascular models, using fat tissue as a high-yield source of stromal vascular cells (co-winner of internal poster prize) Developed new 3D perfusable vascular network models from multiple commercially available platforms - Recruited and trained of a team to adapt these systems to organoidvascularization - Evaluated photopatterning device for fast chip prototyping and for organoid culture automation Designed outsourcing strategies for the development of advanced fibrosis assays in the context of Roche's IBD portfolio. Member of the Digital Strategy core (agile) team, helping shaping the strategy for a compliant and FAIR image storage and processing Created/Animated the Vascular Biology Community Member of the 6th cohort of the Entrepreneurship program, on patient-led drug discovery. 2018 L'Oréal R&I — Lab leader Regenerative Medicine Lab, Dermis Physiology Group As a lab head, my responsibilities involved: Strategic planning for an interdisciplinary multiscale clinical study on stem cell therapy for facial skin repair/rejuvenation Lab management: - People development. Recruitment/Retirements - Data Management and Digital transformation around Good Data Practices in the lab. - Coordination with platforms (Pollutants bioanalytics, Imaging, Tissue Engineering, Episkin, Bioinformatics, Biomechanics) - Development of techniques (tissue dissociation, FACS strategy, spheroid culture/banking, stem cell quality controls) 2015 2018 L'Oréal R&I — Omics Data Scientist Digital Biology Lab Omics statistical and machine learning models for clinical data and reconstructed skin data analysis and cosmetics/drug repositioning: Full Stack development from Mathematical model generation, data integration, parallel computing optimization to final data visualization (UI+UX) and documentation for further outsourcing Biological interpretation of the data and Generation of actionable insights for biological/- clinical validation: Proposals for new targets in hair regeneration, skin aging | Proposals for drug repurposing | Validation strategy Master student mentorship for new correlation network-based systems Participation in academic chair on ML for multi-omics correlation of in vitro and ex-vivo models of skin reconstruction Benchmarking commercial solutions, from deep learning-aided drug repurposing in ageing to muti-omics pathway scoring Consultant in the Biomaterials and Tissue Engineering task forces # ENTREPRENEURSHIP 2022 2023 twinvitro — co-Founder and Chief Scientific Officer co-built the business plan, pitch deck designed the graphic identity of the company raised 50 k€ from Nubbo incubator to enter their young startup program 2017 2018 One Young World — Ambassador, Project leader Represented L'Oréal Research & Innovation at the One Young World 2017 Summit in Bogota Created and led a winner project from L'Oréal's Call to Action post OYW2017 Pitched the project in a Go/No-Go session with L'Oréal's CEO (Jean-Paul Agon), and got approval to enter the pilot phase 2014 EZBio.net/YoyoStudios — Founder and Developer Apps : ezPregnancy (Android + iOS) | ZotEZ2 (Android) | Aziz Lite suite (Android): ZotEZ, MendEZ, EZPaperz Games (Android + iOS) : Fried Chicken | Chicken Pinball | Snake n' Bees # ACADEMIC EXPERIENCES 2011 2015 Université de Paris|CRI Paris — PhD student, Project leader Labs of Ph. Menasché (PARCC | HEGP | INSERM) and Y. Chen (IPGG | ENS Paris | PSL) As part of a multi-hospital translational collaboration: Designed the biomaterials used as a cardiac patch in the world first clinical trial delivering hESC-derived cardiovascular progenitor cells onto the heart of patients with chronic heart failure Developed QC assays for translational and rapid assessment of the biomaterials mechanical properties Foundational questions after approval to start clinical trials had been granted: Created microfabricated assays to question the effect of biomaterials on PSCs’ cardiovascular differentiation Studied the joint effect of topography and matrix elasticity on hiPSCs’ cardiomyocyte differentiation Developed pipelines and softwares for systematic assessment of cardiac organoid beating properties Applied results from cardiac organoid beating properties to the design of a “single-dish" high-yield iPS differentiation strategy to cardiomyocytes. Designed transfer technique to create a clinically relevant patch from cardiac bands with highly anisotropic contractility on soft, patterned hydrogels. This closed the loop from the clinics, back to the lab, and then again to the clinics. Lab 1: Microfluidics,Nanotechnology (PI: Y. CHEN) CNRS UMR 8640 - Ecole Normale Supérieure de Paris Lab 2: Cell therapy in cardiovascular diseases (PI: Ph. Menasché) INSERM U970 - HEGP Doctoral School: Frontières du Vivant (FdV) PhD Programme – Centre de Recherches Interdisciplinnaires 2010 2011 Harvard University|Wyss Institute — Research Associate K. K. Parker's Lab Cardiac tissue engineering for integration into a heart-and-lung on a chip system Main techniques: soft lithography, micropatterning, cardiomyocyte culture, contractility assays by image processing, AFM, FT-IR, confocal microscopy 2009 2010 Imperial College London — Research Intern M. Stevens' Lab Design of alginate-based bioactive micro-scaffolds for bone regeneration Main techniques: peptide/hydrogel/polymer synthesis, electrospraying, NMR, SEM, protein assays, stem cell culture 2009 Berkeley Lab — Research associate S.W. Lee's Bio-nanomaterials Lab Genetic engineering of M13/AAV hybrid viral vectors for gene delivery and tissue engineering scaffolds Main techniques: bacterial culture, viral amplification, cloning, electrophoresis 2007 2008 Ecole Polytechnique — Research Team Project T. Gacoin’s Condensed Matter Physics Lab Optimization of the silanisation step in the fabrication of DNA microarrays Main techniques: silanisation, mesoporous/sol-gel silica, ATR-IR, colloidal Au assays # TEACHING EXPERIENCES 2012 2014 ParisTech|Paris Descartes University — Teaching Assistant, Lecturer Master in Biomedical Engineering Creation and Teaching of the "Biomedical Modeling" course in the Biomedical Engineering Master Program Examples of Projects: Engineered heart tissue and muscular thin film contractility assays by video analysis Limb motion modeling for bio-inspired robotics Modeling wave behavior of retinal neuronal networks during development Monte-Carlo models of cellular locomotion In silico simulations of soft matter and elasticity measurement by pipette aspiration experiments 2011 2012 CRI Paris|Université de Paris — Teaching Assistant Frontiers in Life Sciences Bachelor Program Course: Physics and Computer Science Topics: Solid point mechanics, hydrostatics, fluid dynamics, thermodynamics, basic programming, 'Processing' language. Interdisciplinary project: The physics behind Angry Birds # OTHER WORK EXPERIENCES 2008 Yangshuo and Guilin Backstreet International Youth Hostels (Guangxi, China) — Intern Blue-collar internship consisting in: - helping the Chinese receptionists by acting as an interpreter between the English-, Spanish-, French-speaking tourists and them. - cleaning bedrooms - taking orders/serving breakfasts 2006 2007 City and Regional Planning Department of Boulogne-Billancourt City Government (France) — Intern, Civil Servant Financial and legal consulting for French Private Finance Initiative (PFI) contracts:   - "Design, construction and maintenance of an eco-friendly automated waste collection network in the new boroughs of Boulogne-Billancourt"   - "Design, construction and maintenance of a tramway line accross Boulogne-Billancourt" Computational modeling and statistical consulting for a Regional Master Plan preparation:   - "Statistical analysis of the displacement of the employment barycenter in the Greater Paris Area over the last 13 years. Can we model this evolution and predict future trends?"   - Data collection and curation from online sources   - Mathematical model implementation   - Design of a web interface for rapid tuning of the model   - Presentation of the results (documentation, final report) to the City Government's Director-General of Services.  # EDUCATION 2011 2015 Sorbonne Paris Cité | Paris Descartes | Ecole Normale Supérieure de Paris — Ph.D. in Biomaterials and Regenerative Medicine, with very high honors Stem cell and cardiomyocyte mechanobiology, Cardiac patches for heart regeneration. Biomaterial-based hiPSC differentiation-on-a-chip 2009 2010 Imperial College London — M.Sc. in Biomedical Engineering with Distinction Biomechanics, Biomaterials, Tissue Engineering 2006 2010 Ecole Polytechnique — B.Eng., M.Eng. (Ingénieur Polytechnicien, X2006) Biology, Material Science 2004 2006 Preparatory Program for French “Grandes Ecoles” Mathematics, Physics and Chemistry # ONLINE COURSES 2020 Machine Learning with TensorFlow on Google Cloud Platform Google Cloud Specialization 1 2016 Machine Learning Specialization University of Washington + Dato (now Turi, now part of Apple) Foundations: a case study approach Regression Classification Course was interrupted after Dato/Turi's acquisition by Apple # LANGUAGES/COMPUTER SKILLS Languages French: native language English: fluent Spanish: fluent Mandarin Chinese: basic German: notions Computer Advanced knowledge in web development, software development and mathematical modeling. Git, Java, R, Python, Google Cloud ML, Swift/iOS dev, Matlab, Android dev, Processing P55, Apex/Oracle, HTML/CSS/Javascript, PHP/MySQL, Microsoft Office, VBA... +Graphical Design tools: Prezi/Sozi, Adobe Illustrator/Inkscape, Adobe Photoshop, AutoCAD,... # SKILLS # OUTSIDE INTERESTS Sports Running (marathons), Adventure Racing (Running + Biking + Kayaking), Skiing, Skydiving Music Piano (13 years of conservatory) at the competitive level pre-professional. Composer # SCIENTIFIC PUBLICATIONS 2020 Human Retinal Microvasculature‐on‐a‐Chip for Drug Discovery Héloïse Ragelle, Karen Dernick, Sonia Khemais, Cordula Keppler, Lucien Cousin, Yohan Farouz, Chris Louche, Sascha Fauser, Stefan Kustermann, Mark W. Tibbitt Peter D. Westenskow Advanced Healthcare Materials 2015 Designing biomaterials for controlled cardiac stem cell differentiation and enhanced cell therapy in the treatment of congestive heart failure Yohan  Farouz PhD Manuscript 2015 M13 bacteriophage and Adeno-Associated Virus Hybrid for Novel Tissue Engineering Material with Gene Delivery Functions So Young Yoo, Hyo-Eon Jin, Dong Shin Choi, Masae Kobayashi, Yohan Farouz, Sky Wang, Seung-Wuk Lee Advanced Healthcare Materials 2015 Safety, Regulatory, and Ethical Issues of Human Studies Yohan Farouz,Mathilde Cossé, Nisa Renault, Philippe Menasché Chapter from book "Biomaterials in cardiac regeneration". Springer International Publishing (2015) 2014 Long Term Functional Benefits Of Human Embryonic Stem Cell-Derived Cardiac Progenitors Embedded Into A Fibrin Scaffold Valérie Bellamy, Valérie Vanneaux, Alain Bel, Hany Nemetalla, Solène Emmanuelle Boitard, Yohan Farouz, Pierre Joanne, Marie-Cécile Perier, Estelle Robidel, Chantal Mandet, Albert Hagège, Patrick Bruneval, Jérôme Larghero, Onnik Agbulut, Philippe Menasché The Journal of Heart and Lung Transplantation published online Nov. 7, 2014 2014 Growing hearts in the right place: on the design of biomimetic materials for cardiac stem cell differentiation Yohan Farouz, Yong Chen, André Terzic, Philippe Menasché Stem Cells published online Dec. 24, 2014 2014 Towards a clinical use of human embryonic stem cell-derived cardiac progenitors: a translational experience. Philippe Menasché, Valérie Vanneaux, Jean-Roch Fabreguettes, Alain Bel, Lucie Tosca, Sylvie Garcia, Valérie Bellamy, Yohan Farouz, Julia Pouly, Odile Damour, Marie-Cécile Périer, Michel Desnos, Albert Hagège, Onnik Agbulut, Patrick Bruneval, Gérard Tachdjian, Jean-Hugues Trouvin, Jérôme Larghero European Heart Journal first published online May 16, 2014 2013 Micropatterning Alginate Substrates for In Vitro Cardiovascular Muscle on a Chip Ashutosh Agarwal*, Yohan Farouz*, Alexander Peyton Nesmith, Leila F. Deravi, Megan L. McCain, Kevin Kit Parker.*AA and YF contributed equally to this work. Advanced Functional Materials (2013) 2012 Réparer les coeurs brisés et les vaisseaux abîmés (Mending broken hearts and repairing damaged blood vessels) Yohan Farouz, Yong Chen, Philippe Menasché, Julia Ino, Michael Atlan, Catherine Le Visage, Didier Letourneur Biofutur 335, p30-33 (September 2012) # CONFERENCE PARTICIPATIONS 2013 Mechanical characterization of new clinically relevant fibrin-based hydrogels for heart repair using shear wave ultrasound elastography Mathieu Pieronne, Mathieu Pernot, Joevin Sourdon, Yong Chen, Alba Marcellan, Philippe Menasche, Yohan Farouz Oral communication at the MRS Fall Meeting 2013 (December 2013) 2012 Engineering Anisotropic Cardiovascular Muscle on Alginate Surfaces for in vitro Contractility Assays Ashutosh Agarwal, Yohan Farouz, Alexander Peyton Nesmith, Leila F. Deravi, Megan L. McCain, Kevin Kit Parker. Oral communication at the MRS Fall Meeting 2012 (November 2012) 2011 Alginate-based muscular thin films for in vitro cardiac contractility assays Yohan Farouz, Ashutosh Agarwal, Megan L. McCain, Kevin Kit Parker Poster presentation for the BMES Conference 2011 (October 2011) 2011 Alginate-based muscular thin films for in vitro cardiac contractility assays Yohan Farouz, Ashutosh Agarwal, Megan L. McCain, Kevin Kit Parker Oral communication for the MRS Conference 2011 (November 2011) # INVITED TALKS AND POSTERS 2015 Growing hearts in the right place: on the design of biomimetic materials for cardiac stem cell differentiation. Yohan Farouz, Yong Chen, Philippe Menasché Poster presentation at the "Integrative Biology in metabolic and cardiovascular diseases" Summer school, 2015 2014 Translating stem cell mechanobiology to the clinics: high-throughput mechanical characterization of clinically relevant materials for cardiac cell therapy Yohan Farouz, Pierre Joanne, Mathieu Pieronne, Yong Chen, Philippe Menasché Oral communication at the Revive Annual Consortium Meeting, 2014 2013 Microengineering materials to study the cardiovascular differentiation of embryonic stem cells and promote their engraftment onto the infarcted myocardium Yohan Farouz, Yong Chen, Philippe Menasché Oral Communication at the Annual Young Researchers' day of the Chemistry Department, ENS Paris, 2013 2013 Microengineering materials to study the cardiovascular differentiation of embryonic stem cells and promote their engraftment onto the infarcted myocardium Yohan Farouz, Yong Chen, Philippe Menasché Poster presentation at the Annual PARCC retreat, 2013 # HONORS AND AWARDS 2014 2015 Fondation pour la Recherche Medicale Promising young researcher scholarship 2011 2014 Ecole Polytechnique Scholarship for doctoral research 2011 2014 Ecole Doctorale Frontières du Vivant (FdV) - Programme Bettencourt Training and Traveling awards 2010 M. Sc. in Biomedical Engineering, with Distinction Biomechanics, Biomaterials, Tissue Engineering 2010 2011 France Fulbright Scholarship (through Fondation Monahan) Scholarship for a 10-month research internship at Harvard University 2009 2010 Edward and Eva Underwood Foundation Scholarship for studies at Imperial College London 2004 2010 Ecole Polytechnique Scholarship for top French engineering students (4 years of funding) 2004 French Baccalauréat with very high honors